Search results for "Physiological function"
showing 9 items of 9 documents
Lärm als Umweltproblem
1976
Noise as an Environmental Problem. Anatomical structure and physiological function of the human ear are described. It is shown that constant noise stress leads to damage of certain parts of the inner ear. These damages proceed characteristically and may be diagnosed relatively early by means of audiometric tests. VDI-instructions 2058 (sheet 2) prescribes screening-tests for an earliest possible detection of incipient noise damage. In addition to ear-damaging effects of noise there have also been recorded physiological reactions under noise influence. Such disturbances, however, cannot as yet be described as an “Extraaural disease”. On the other hand, the fact that high sound intensities of…
Ligand-binding assays with OBPs and CSPs
2020
Assessing the ligand-binding properties of OBPs and CSPs is essential for understanding their physiological function. It also provides basic information when these proteins are used as biosensing elements for instrumental measurement of odors. Although different approaches have been applied in the past to evaluate the affinity of receptors and soluble binding proteins to their ligands, using a fluorescent reporter represents the method of choice for OBPs and CSPs. It offers the advantages of working at the equilibrium, being simple, fast and inexpensive, without requiring the use of radioactive tracers. However, as an indirect method, the fluorescence competitive binding approach presents d…
Adenine nucleotide metabolism during anoxia and postanoxic recovery in insects
1996
Severe hypoxia (anoxia), if maintained for more than a few minutes, causes irreversible damage in humans and other mammals. Why mammals are so vulnerable to anoxia is not fully understood. It is therefore of interest to study animals that are more tolerant of anoxia in order to identify physiological and metabolic properties that are correlated with a high tolerance of anoxia. Insects have high metabolic rates and their energy metabolism is dependent on aerobic ATP production. In insects, as in mammals, anoxia causes a rapid breakdown of physiological function, resulting in a state similar to rigor mortis. This is accompanied by a precipitous decrease in metabolic rate. In contrast to mamma…
Identification of calcium sensing receptor (CaSR) mRNA-expressing cells in normal and injured rat brain
2009
Calcium sensing receptor (CaSR), isolated for the first time from bovine and human parathyroid, is a G-protein-coupled receptors that has been involved in diverse physiological functions. At present a complete in vivo work on the identification of CaSR mRNA-expressing cells in the adult brain lacks and this investigation was undertaken in order to acquire more information on cell type expressing CaSR mRNA in the rat brain and to analyse for the first time its expression in different experimental models of brain injury. The expression of CaSR mRNAs was found mainly in scattered cells throughout almost all the brain regions. A double labeling analysis showed a colocalization of CaSR mRNA expr…
''No Gender Difference in Peak Performance in Ultra-Endurance Swimming Performance - Analysis of the 'Zurich 12-h Swim' from 1996 to 2010''
2012
Eichenberger, Evelyn | Knechtle, Beat | Christoph, Alexander Rust | Knechtle, Patrizia | Lepers, Romuald | Rosemann, Thomas; International audience; ''The aims of the study were to [1] investigate the performance trends at the 'Zurich 12-h Swim' in Switzerland from 1996 to 2010; and [2] determine the gender difference in peak performance in ultra-endurance swimming. In total, 113 male and 53 female swimmers competed in this indoor ultra-endurance event while swimming in a heated pool. The number of male participants significantly increased (r(2) = 0.36, P = 0.04) over time while the participation of females remained unchanged (r(2) = 0.12, P = 0.26). In the age group 0.05). The best perform…
Investigations on the geographical variability of the human transferrins.
1971
On the basis of own and from the widely scattered literature compiled materials the geographical distribution of the transferrin alleles is discussed. They reveal a characteristic distribution pattern, as the slow Tf variants produced by TfD alleles are obviously more frequent in tropical than in non-tropical populations. Considering similar results in cattle and its interpretation by Ashton (1958, 1965), it is hypothesized, that the relatively high TfΓ frequencies in tropical biotops might be a selective adaptation to their special climatic conditions. In this connection an association between slowly moving transferrin proteins in man and tolerance to hotter climates — as could be found in…
Anti-Aging Physiological Roles of Aryl Hydrocarbon Receptor and Its Dietary Regulators
2021
The vast majority of the literature on the aryl hydrocarbon receptor is concerned with its functions in xenobiotic detoxification. However, in the course of evolution, this receptor had to have physiological (rather than toxicological) functions. Our aim was to review the aryl hydrocarbon receptor’s role in the physiological functions involved in aging. This study was performed by searching the MEDLINE and Google Academic databases. A total of 34 articles were selected that focused specifically on the aryl hydrocarbon receptor and aging, the aryl hydrocarbon receptor and physiological functions, and the combination of both. This receptor’s main physiological functions (mediated by the modul…
Fundamentals on the Molecular Mechanism of Action of Antimicrobial Peptides
2019
Abstract Antimicrobial peptides (AMPs) are produced by several organisms as their first line of defense. Constituted by amino acids, they may present different mechanisms of action. The antimicrobial activity can be used by the peptide-producing organism itself, as innate immune strategy, or in the industry, applying as natural source preservatives. Understanding the possibilities of the operation of these compounds is a prerequisite for the development of effective uses, as well as for the establishment of combinations, which can even expand their applications considering the possibilities of genetic manipulations. Thus, the objective of this article is to review the basic principles of AM…
The changes in age of peak swim speed for elite male and female Swiss freestyle swimmers between 1994 and 2012
2014
This study determined the age and its changes across years of peak swimming performance from 50 to 1,500 m freestyle. Data of 70,059 Swiss freestyle swimmers (33,725 women and 36,334 men) aged 10-40 years and competing from 50 to 1,500 m were analysed. The association between age and swimming speed of the annual ten fastest swimmers was investigated using single and multi-level hierarchical regression analyses. For women, age of peak swimming speed increased in 50 m from 18.9 (s = 2.3) to 20.4 (s = 4.2) years but decreased in 1,500 m from 25.0 (s = 13.1) (1996) to 18.1 (s = 3.7) years. For 100-800 m, age remained at 19.1 (s = 1.1), 19.3 (s = 1.1), 18.7 (s = 1.5) and 18.5 (s = 1.3) years, re…